CD85G Antibody (YA4112)

CD85G Antibody (YA4112) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD85G. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.

CD85G functions as a coreceptor to limit innate immune responses to viral infections via FCER1G-mediated signaling. It downregulates the production of IFNA1, IFNA2, IFNA4, IFNB1, and TNF by plasmacytoid dendritic cells exposed to influenza virus or CpG dinucleotides, acting as a negative regulator of TLR7 and TLR9 signaling cascades. Additionally, CD85G suppresses interferon production through interaction with BST2 on HIV-1-infected cells. In complex with FCER1G, it activates a signaling cascade leading to phosphorylation of Src family and Syk kinases, triggering intracellular Ca²⁺ mobilization. Notably, CD85G does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells. by similar: These functions align with CD85G's central role in immune regulation.

P59901

Predicted band size: 55.2 kDa; Observed band size: 55 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CD85G (AA: extra 24-178) expressed in E. Coli.