CEACAM1 Antibody (YA3788)

CEACAM1 Antibody (YA3788) is a mouse-derived and non-conjugated IgG2b antibody, targeting to CD66A. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human.

CEACAM1 protein, functioning as a cell adhesion molecule, mediates homophilic cell adhesion in a calcium-independent manner. It plays a multifaceted role as a coinhibitory receptor in immune responses and insulin action, while also serving as an activator during angiogenesis. Through phosphorylation- and PTPN6-dependent mechanisms, CEACAM1 suppresses signal transduction of associated receptors, inhibiting T-cell cytotoxicity, proliferation, and cytokine production. Moreover, it regulates autoimmunity and anti-tumor immunity by interacting with HAVCR2. In NK cells, it inhibits KLRK1-mediated cytolysis and negatively regulates IL1B production in neutrophils. CEACAM1 down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R, and it also regulates insulin action by promoting INS clearance and controlling lipogenesis in the liver. Furthermore, it functions as an activator in angiogenesis, promoting blood vessel remodeling and arteriogenesis. CEACAM1 regulates vascular permeability, down-regulates cell growth in response to EGF, inhibits platelet aggregation, negatively regulates osteoclastogenesis, and contributes to the regulation of IgA production and secretion associated with microbiota control and resistance to enteropathogens.

P13688

Predicted band size: 58 kDa; Observed band size: 120-150 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Purified recombinant fragment of human CD66A (AA: extra 65-201) expressed in E. Coli.