CD43 Antibody (YA802)

CD43 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 40 kDa, targeting to CD43. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human.

The CD43 protein stands out as the predominant cell surface sialoprotein of leukocytes, orchestrating a myriad of crucial functions in T-cell regulation. It exerts a positive influence on T-cell activation, proliferation, differentiation, trafficking, and migration, notably facilitating T-cell trafficking to lymph nodes through its association with ERM proteins (EZR, RDX, and MSN). While playing a role in preparing T-cells for cytokine sensing and differentiation into effector cells, CD43 negatively regulates Th2 cell differentiation and steers T-cells toward a Th1 lineage commitment. Additionally, it plays a pivotal role in inducing the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation, promoting IFNGR and IL4R signaling, and mediating the clustering of IFNGR with TCR. Acting as a major E-selectin ligand, CD43 facilitates Th17 cell rolling on activated vasculature and recruitment during inflammation, mediating Th17 cell adhesion to E-selectin. Moreover, CD43 serves as a T-cell counter-receptor for SIGLEC1, contributing to cell survival by protecting cells from apoptotic signals.

Free

P16150

Predicted band size: 41 kDa; Observed band size: 55 kDa

Protein G affinity purified.

Membrane, microvillus, uropodium, Nucleus, PML body.

Non-conjugated

Unmodified

Immunology

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

Human

WB: 1:500; IHC-P: 1:200-1:1,000; FC: 1:50-1:100

WB, IHC-P, FC

WB, IHC-P, FC

Liquid

Supplied in 1*PBS (pH7.4), 0.2% BSA and 50% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Endogenous

Synthetic peptide corresponding to Human CD43.The exact sequence is proprietary to MCE.