CD35 Antibody (YA5699)

CD35 Antibody (YA5699) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD35. It can be applicated for IHC-P, ELISA assays, in the background of human.

CD35 is a membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. It mediates the binding of these cells to particles and immune complexes that have activated complement, facilitating their elimination from circulation. Additionally, CD35 inhibits spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases and acts as a cofactor for factor I-mediated cleavage of C3b to iC3b, C3c, and C3d,g, as well as C4b to C4c and C4d. CD35 also contributes to immune regulation by promoting the generation of regulatory T cells from activated helper T cells upon ligand binding; (by similar microbial infection function) serves as a receptor for Epstein-Barr virus.

P17927

Predicted band size: 223 kDa; Observed band size: 250 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

IHC: 1:200-400; ELISA: 1:500-5000

IHC-P, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Synthesized peptide derived from human CD35 AA range: 300-400