CD35 Antibody (YA1328)

CD35 Antibody (YA1328) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1328), targeting CD35. CD35 Antibody (YA1328) can be used for IHC-P experiment in human background.

CD35 is a membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. It mediates the binding of these cells to particles and immune complexes that have activated complement, facilitating their elimination from circulation. Additionally, CD35 inhibits spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases and acts as a cofactor for factor I-mediated cleavage of C3b to iC3b, C3c, and C3d,g, as well as C4b to C4c and C4d. CD35 also contributes to immune regulation by promoting the generation of regulatory T cells from activated helper T cells upon ligand binding; (by similar microbial infection function) serves as a receptor for Epstein-Barr virus.

P17927

Predicted band size: 224 kDa; Observed band size: 280 kDa

Affinity Purified

Non-conjugated

Unmodified

AB_3103695

Immunology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

IHC: 1/100-1/200

IHC-P

Liquid

Supplied in PBS only.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human CD35