CD307C Antibody (YA4434)

CD307C Antibody (YA4434) is a mouse-derived and non-conjugated IgG2a antibody, targeting to CD307C. It can be applicated for WB, FC, ELISA assays, in the background of human.

CD307C is a multifunctional protein with dual roles in B cells: it promotes TLR9-induced B-cell proliferation, activation, and survival while inhibiting antibody production and plasma cell differentiation by enhancing NF-kappa-B and MAPK signaling pathways. Conversely, it potentially inhibits B-cell receptor (BCR)-mediated signaling through association with SH2 domain-containing phosphatases, thereby reducing cell tyrosine phosphorylation, calcium mobilization, and BCR-induced activation-dependent cell death. by similar: Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, show reduced responsiveness to antigenic stimulation in the presence of IL2, and have diminished capacity to suppress effector T-cell proliferation. Additionally, CD307C acts as a human-specific epitope on the oocyte surface (oolemma), interacting with the IZUMO1-IZUMO1R/JUNO sperm-egg complex to replace IZUMO1R/JUNO as the IZUMO1 receptor during fertilization, enabling species-specific gamete fusion.

Q96P31

Predicted band size: 80.9 kDa; Observed band size: 51 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Purified recombinant fragment of human CD307C (AA: extra 18-153) expressed in E. Coli.