CD300F Antibody (YA4381)

CD300F Antibody (YA4381) is a mouse-derived and non-conjugated IgG2b antibody, targeting to CD300F. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

CD300F acts as an inhibitory receptor in myeloid cells and mast cells. It positively regulates the phagocytosis of apoptotic cells (efferocytosis) by recognizing phosphatidylserine (PS) on their surface, playing a key role in immune homeostasis maintenance (By similarity). Additionally, CD300F negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses by binding to ceramide and sphingomyelin. It may function as a coreceptor for interleukin 4 (IL-4), enhancing IL-4- and IL-13-induced signaling to modulate IL-4 receptor alpha-mediated responses (By similarity). CD300F also inhibits Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Furthermore, it suppresses osteoclast formation and induces macrophage cell death upon engagement (By similarity).

Q8TDQ1

Predicted band size: 32.3 kDa; Observed band size: 32 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Purified recombinant fragment of human CD300F (AA: Extra(20-156)) expressed in E. Coli.