CD226 Antibody (YA2412)

CD226 Antibody (YA2412) is a non-conjugated IgG antibody, targeting CD226, with a predicted molecular weight of 39 kDa (observed band size: 60-80 kDa). CD226 Antibody (YA2412) can be used for WB experiment in human background.

CD226 is a cell surface receptor that plays a critical role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity, and lymphokine secretion mediated by cytotoxic T-cells and NK cells. It functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells enhances the cytotoxic activity of NK cells and CTLs, improving their ability to eliminate these cells. Mechanistically, phosphorylation by Src kinases (e.g., LYN or FYN) enables interaction with the adapter protein GRB2, leading to activation of VAV1, PI3K, and PLCG1. Additionally, it promotes the activation of kinases ERK and AKT, as well as calcium fluxes (By similarity).

Q15762

Predicted band size: 39 kDa; Observed band size: 60-80 kDa

Affinity Purified

Non-conjugated

Unmodified

Immunology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000

WB

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human CD226