CCR6 Antibody (YA4072)

CCR6 Antibody (YA4072) is a mouse-derived and non-conjugated IgG2a antibody, targeting to CD196. It can be applicated for WB, FC, ELISA assays, in the background of human.

The CCR6 Protein acts as a receptor for the C-C type chemokine CCL20, transducing signals by increasing intracellular calcium ion levels upon binding to its major ligand. Notably, CCR6 can also function as a receptor for non-chemokine ligands, such as beta-defensins, including DEFB1, DEFB4, and DEFB4A/B. The interaction between CCR6 and DEFB1 is crucial for regulating sperm motility and bactericidal activity. Additionally, CCR6 plays a pivotal role in chemotaxis, being responsible for the migration of dendritic cells, effector/memory T-cells, and B-cells, particularly at skin and mucosal surfaces under various conditions, including inflammation and pathology such as cancer and autoimmune diseases. CCR6-mediated signals are essential for immune responses in the intestinal mucosa, modulating inflammatory responses to tissue insult and trauma. Moreover, CCR6 is indispensable for recruiting pro-inflammatory IL17-producing helper T-cells (Th17) and regulatory T-cells (Treg) to sites of inflammation, influencing thymocyte precursor migration events, B-cell localization in Peyers-patches, and the efficient secondary recall response of memory B-cells. It also positively regulates sperm motility and chemotaxis through its binding to CCL20.

P51684

Predicted band size: 42 kDa; Observed band size: 42 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Purified recombinant fragment of human CD196 expressed in E. Coli.