ADAM17 Antibody (YA4137)

ADAM17 Antibody (YA4137) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD156B. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human, mouse.

CD156B is a transmembrane metalloprotease that mediates the ectodomain shedding of numerous transmembrane proteins, including adhesion proteins, growth factor precursors, and cytokines critical for inflammation and immunity. It cleaves the membrane-bound precursor of TNF-alpha into its mature soluble form and facilitates the proteolytic release of soluble JAM3 from endothelial cell surfaces. Additionally, CD156B is responsible for shedding other cell-surface proteins such as p75 TNF receptor, interleukin-1 receptor type II, p55 TNF receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and amyloid precursor protein. It activates the Notch pathway by cleaving Notch to generate the membrane-associated intermediate fragment NEXT and plays a role in the proteolytic processing of ACE2. In hemostasis, CD156B sheds GP1BA (the platelet glycoprotein Ib alpha chain) (by similarity). It also mediates the proteolytic cleavage of LAG3 and IL6R, releasing their soluble forms (LAG3 by similarity; IL6R supported by references). Upon NK cell stimulation, CD156B cleaves FCGR3A, enhancing NK cell motility and detachment from opsonized targets. Furthermore, it cleaves TREM2, resulting in ectodomain shedding.

P78536

Predicted band size: 93 kDa; Observed band size: 100 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse

WB: 1/500-1/2000; IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CD156B (AA: 497-671) expressed in E. Coli.