IFNGR1 Antibody (YA3806)

IFNGR1 Antibody (YA3806) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD119. It can be applicated for WB, FC, ELISA assays, in the background of human.

CD119 is a receptor subunit for interferon gamma (INFG) that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. It associates with the transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. Activated JAK1 then phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner, although activation appears weaker. Phosphorylation of the IFNGR1 intracellular domain also provides a docking site for SOCS1, which regulates the JAK-STAT pathway by competing with STAT1 for binding to IFNGR1 (By similarity).

P15260

Predicted band size: 54 kDa; Observed band size: 45-100 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CD119 (AA: extra 18-245) expressed in E. Coli.