CaMKII beta Antibody (YA2344)

CaMKII beta Antibody (YA2344) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII beta.

CaMKII β is a calcium/calmodulin-dependent protein kinase that operates autonomously following Ca²⁺/calmodulin binding and autophosphorylation, playing roles in dendritic spine/synapse formation, neuronal plasticity, and regulation of sarcoplasmic reticulum Ca²⁺ transport in skeletal muscle. In neurons, it structurally reorganizes the actin cytoskeleton during plasticity by kinase-independent actin filament bundling, enabling proper targeting of CaMK2A to promote synaptic plasticity underlying long-term potentiation (LTP) and hippocampus-dependent learning. It facilitates dendritic arborization in developing hippocampal neurons and remodeling in mature neurons, while also regulating neuronal migration. In skeletal muscle, it modulates function during exercise: regulating SR Ca²⁺ transport in slow-twitch fibers and controlling Ca²⁺ release via phosphorylation of triadin and phospholamban in fast-twitch fibers. Upon IFN-γ stimulation, it phosphorylates STAT1 to activate JAK-STAT signaling (By similarity). Under ER stress, it phosphorylates RETREG1 at Ser-151 to enhance its oligomerization and reticulophagy activity.

Q13554

Predicted band size: 73 kDa; Observed band size: 54 kDa

Affinity Purified

Non-conjugated

Unmodified

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Mouse

WB: 1:500-1:1000

WB

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human CaMKII aa209-226.