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  5. Calsequestrin 1 Antibody (YA1561)

Calsequestrin 1 Antibody (YA1561)

Cat. No.: HY-P81816
User Guide for Antibodies Technical Support

Calsequestrin 1 Antibody (YA1561) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1561), targeting Calsequestrin 1, with a predicted molecular weight of 45 kDa (observed band size: 63 kDa). Calsequestrin 1 Antibody (YA1561) can be used for WB, IHC-P, FC experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Calsequestrin 1 Antibody (YA1561) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1561), targeting Calsequestrin 1, with a predicted molecular weight of 45 kDa (observed band size: 63 kDa). Calsequestrin 1 Antibody (YA1561) can be used for WB, IHC-P, FC experiment in human, mouse, rat background.
Background

Calsequestrin 1, a high-capacity calcium-binding protein, serves as an internal calcium store in muscle. Clusters of acidic residues at the protein surface, particularly at the subunit interface, facilitate the binding of approximately 80 Ca(2+) ions. This protein plays a pivotal role in regulating the release of lumenal Ca(2+) through the calcium release channel RYR1, thereby contributing to the initiation of muscle contraction. Additionally, Calsequestrin 1 acts as a negative regulator of store-operated Ca(2+) entry (SOCE) activity. Existing as a monomer that increases in response to intracellular calcium depletion, it can also form homodimers and higher-order homooligomers, with Ca(2+) ions promoting oligomerization. Calsequestrin 1 interacts with STIM1, preferentially in its monomeric form, and this interaction intensifies following intracellular calcium depletion. Furthermore, it interacts with ASPH and TRDN, highlighting its involvement in diverse cellular processes related to calcium homeostasis.
Gene ID
SwissProt ID
Synonyms
Calmitin; Calmitine; Calsequestrin; Calsequestrin-1; CASQ; Casq1; PDIB1
Molecular Weight

Predicted band size: 45 kDa; Observed band size: 63 kDa
Purity

Affinity Chromatography
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Signal Transduction
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100;FC: 1/50-1/100
Application

WB, IHC-P, FC
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human Calsequestrin 1
Database

Entrez Gene: 844 Human ; 12372 Mouse ; 686019 Rat

SwissProt: P31415 Human ; O09165 Mouse ; P19633 Rat

OMIM: 616231 Human

Documentation
User Guide for Antibodies (1077 KB)

Calsequestrin 1 Antibody (YA1561) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Calsequestrin 1 Antibody (YA1561)
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HY-P81816
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