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  5. Caldesmon/CDM Antibody (YA1301)

Caldesmon/CDM Antibody (YA1301)

Cat. No.: HY-P81556
User Guide for Antibodies Technical Support

Caldesmon/CDM Antibody (YA1301) is a non-conjugated IgG antibody, targeting Caldesmon/CDM, with a predicted molecular weight of 93 kDa (observed band size: 75 kDa). Caldesmon/CDM Antibody (YA1301) can be used for IHC-P experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Caldesmon/CDM Antibody (YA1301) is a non-conjugated IgG antibody, targeting Caldesmon/CDM, with a predicted molecular weight of 93 kDa (observed band size: 75 kDa). Caldesmon/CDM Antibody (YA1301) can be used for IHC-P experiment in human, mouse, rat background.
Background

CALD1 is an actin- and myosin-binding protein implicated in regulating actomyosin interactions in smooth muscle and nonmuscle cells (potentially acting as a bridge between myosin and actin filaments). It stimulates tropomyosin binding to actin, thereby stabilizing actin filament structure. In muscle tissues, CALD1 inhibits actomyosin ATPase activity by binding to F-actin, with this inhibition attenuated by calcium-calmodulin and enhanced by tropomyosin. It interacts with actin, myosin, two tropomyosin molecules, and calmodulin. Additionally, CALD1 plays essential roles in cellular mitosis, receptor capping, and Schwann cell migration during peripheral nerve regeneration (by similar).
Gene ID
SwissProt ID
Synonyms
CALD, CAD, CALD1
Molecular Weight

Predicted band size: 93 kDa; Observed band size: 93 kDa
Purity

Protein A
Subcellular Location

Cytoplasm, Cytoskeleton.
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Tumor biology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:1,000-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:200;FC: 1:1,000
Application

WB, IHC-P, ICC/IF, FC
Positive Control

NIH/3T3 cell lysates, NIH/3T3, C6, human kidney tissue, mouse kidney tissue, rat kidney tissue.
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic peptide within Human Caldesmon aa 744-793 / 793.
Database

Entrez Gene: 800 Human ; 109624 Mouse ; 25687 Rat

SwissProt: Q05682 Human ; Q62736 Rat

OMIM: 114213 Human

Documentation
User Guide for Antibodies (1077 KB)

Caldesmon/CDM Antibody (YA1301) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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