Caldesmon Antibody (YA5529)

Caldesmon Antibody (YA5529) is a mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to caldesmon. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.

CALD1 is an actin- and myosin-binding protein implicated in regulating actomyosin interactions in smooth muscle and nonmuscle cells (potentially acting as a bridge between myosin and actin filaments). It stimulates tropomyosin binding to actin, thereby stabilizing actin filament structure. In muscle tissues, CALD1 inhibits actomyosin ATPase activity by binding to F-actin, with this inhibition attenuated by calcium-calmodulin and enhanced by tropomyosin. It interacts with actin, myosin, two tropomyosin molecules, and calmodulin. Additionally, CALD1 plays essential roles in cellular mitosis, receptor capping, and Schwann cell migration during peripheral nerve regeneration (by similar).

Q05682

Predicted band size: 93 kDa; Observed band size: 93 kDa

Protein G

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

IHC: 1:200-1000; WB: 1:500-2000; ICC/IF: 1:100-500; ELISA: 1:1000-5000

IHC-P, WB, ICC/IF, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Synthesized peptide derived from human Caldesmon pan AA range: 100-200