C5AR2 Antibody (YA4542)

C5AR2 Antibody (YA4542) is a mouse-derived and non-conjugated IgG1 antibody, targeting to C5AR2. It can be applicated for IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

The C5AR2 Protein acts as a receptor for the chemotactic and inflammatory C3a, C4a, and C5a anaphylatoxin peptides, as well as their dearginated forms ASP/C3adesArg, C4adesArg, and C5adesArg, respectively. While it couples weakly to G(i)-mediated signaling pathways, C5AR2 interacts with C3, specifically with higher affinity for ASP, the adipogenic hormone. This interaction enhances the phosphorylation and activation of GPR77, leading to the recruitment of ARRB2 to the cell surface and subsequent endocytosis of GRP77. This intricate signaling mechanism highlights the involvement of C5AR2 in mediating responses to anaphylatoxin peptides and ASP, suggesting its role in modulating immune and inflammatory processes.

Q9P296

Predicted band size: 36 kDa; Observed band size: 36 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human C5AR2 (AA: extra mix) expressed in E. Coli.