C1QA Antibody (YA3624)

C1QA Antibody (YA3624) is a mouse-derived and non-conjugated IgG2a antibody, targeting to C1QA. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

C1QA protein plays a pivotal role in the formation of C1, the initiating component of the serum complement system. C1q associates with the proenzymes C1r and C1s, resulting in the assembly of C1. The collagen-like regions of C1q engage with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 occurs upon the interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibodies within immune complexes. Active C1 constitutes a calcium-dependent trimolecular complex composed of C1q, C1r, and C1s in a molar ratio of 1:2:2. The C1q subcomponent consists of nine subunits, with six forming disulfide-linked dimers of the A and B chains, and the remaining three forming disulfide-linked dimers of the C chain. Additionally, C1QA interacts via its C-terminus with CD33, activating CD33 inhibitory motifs.

P02745

Predicted band size: 26 kDa; Observed band size: 30 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Purified recombinant fragment of human C1QA (AA: 23-167) expressed in E. Coli.