C-MYC Antibody (YA3596)

C-MYC Antibody (YA3596) is a mouse-derived and non-conjugated IgG1 antibody, targeting to C-MYC. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

C-MYC is a transcription factor that binds DNA non-specifically while also recognizing the core sequence 5'-CAC[GA]TG-3'. It activates the transcription of growth-related genes and binds to the VEGFA promoter to promote VEGFA production and sprouting angiogenesis. As a regulator of somatic reprogramming, it controls the self-renewal of embryonic stem cells (by similar). It functions with TAF6L to activate target gene expression through RNA polymerase II pause release (by similar). Additionally, it positively regulates the transcription of HNRNPA1, HNRNPA2, and PTBP1, which modulate the splicing of pyruvate kinase PKM by repressing exon 9 inclusion, leading to exon 10 inclusion and the production of the PKM M2 isoform.

P01106

Predicted band size: 49 kDa; Observed band size: 57 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human C-MYC (AA: (290-439)) expressed in E. Coli.