c-Maf Antibody (YA1178)

c-Maf Antibody (YA1178) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Maf.

c-Maf functions as a transcriptional activator or repressor, playing a role in embryonic lens fiber cell development. During lens fiber cell differentiation, it recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters, upregulating crystallin gene expression. It activates IL4 expression in T helper 2 (Th2) cells and increases T-cell susceptibility to apoptosis by interacting with MYB and reducing BCL2 expression. Together with PAX6, it strongly transactivates the glucagon gene promoter via the G1 element. It activates transcription of the CD13 proximal promoter in endothelial cells but represses it in early myelopoiesis by disrupting the cooperative interaction between ETS1 and MYB. It is involved in initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. It binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter, as well as T-MARE (Maf response element) sites in lens-specific α- and β-crystallin gene promoters. It binds the G1 element on the glucagon promoter and an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). Overexpression suppresses antioxidant response element (ARE)-mediated transcription. Depending on cellular context, it may act as an oncogene or tumor suppressor and binds ARE sites in detoxifying enzyme gene promoters.

O75444

Predicted band size: 38 kDa; Observed band size: 44 kDa

Affinity Purified

Non-conjugated

Unmodified

AB_3103548

Cell Biology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

IHC: 1:100-1:200

IHC-P

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.24.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein of human c-Maf