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  5. c-Fos Antibody (YA506)

c-Fos Antibody (YA506) is a non-conjugated and Rabbit origined monoclonal antibody about 41 kDa, targeting to c-Fos. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human,Mouse,Rat.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

Publications Citing Use of MCE c-Fos Antibody (YA506)

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

c-Fos Antibody (YA506) is a non-conjugated and Rabbit origined monoclonal antibody about 41 kDa, targeting to c-Fos. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human,Mouse,Rat.
Background

c-Fos is a nuclear phosphoprotein that forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, the basic regions of FOS and JUN/AP-1 each interact with symmetrical DNA half-sites. Upon TGF-beta activation, it forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. It plays a critical role in regulating the development of cells destined to form and maintain the skeleton and is thought to be important in signal transduction, cell proliferation, and differentiation. In growing cells, c-Fos activates phospholipid synthesis, likely by activating CDS1 and PI4K2A, an activity that requires Tyr dephosphorylation and association with the endoplasmic reticulum.
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 41 kDa; Observed band size: 41/55 kDa
Purity

Protein A affinity purified.
Subcellular Location

Nucleus, Endoplasmic reticulum, Cytoplasm.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Neuroscience
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Rat
Tested Reactivity

Human, Rat
Dilution Ratio

WB: 1:500 ;IHC-P: 1:50-1:200 ;ICC/IF: 1:100
Application

WB, IHC-P, ICC/IF
Tested Applications

WB, IHC-P, ICC/IF
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic peptide corresponding to Human c-Fos.AA range:231-268.
Database

Entrez Gene: 2353 Human ; 14281 Mouse ; 314322 Rat

SwissProt: P01100 Human ; P01101 Mouse ; P12841 Rat

OMIM: 164810 Human

Documentation
SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

c-Fos Antibody (YA506) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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c-Fos Antibody (YA506)
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HY-P80081
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