2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. BRCA1 Antibody (YA819)

BRCA1 Antibody (YA819) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BRCA1.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

BRCA1 Antibody (YA819) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BRCA1.
Background

BRCA1 is an E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates diverse cellular pathways such as DNA damage repair, ubiquitination, and transcriptional regulation to maintain genomic stability. Additionally, it regulates centrosomal microtubule nucleation and is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and G2 phase. BRCA1 is also involved in targeting FANCD2 to sites of DNA damage, inhibits lipid synthesis by binding to inactive phosphorylated ACACA, and contributes to homologous recombination repair (HRR) through its interaction with PALB2. As part of the BRCA1-RBBP8 complex, it regulates CHEK1 activation and controls the G2/M checkpoint following DNA damage via BRCA1-mediated ubiquitination of RBBP8. BRCA1 also functions as a transcriptional activator.
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 208 kDa; Observed band size: 208 kDa
Purity

Protein A affinity purified.
Subcellular Location

Cytoplasm, Nucleus, Chromosome.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Mouse Monoclonal Antibody
Clonality

Monoclonal
Host

Mouse
Reactivity

Human, Mouse
Dilution Ratio

IHC-P: 1:1,500
Application

IHC-P
Appearance

Liquid
Formulation

Supplied in 1*PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG1
Sensitivity

Endogenous
Immunogen

Synthetic peptide corresponding to Human BRCA1.AA range:1-200.
Database

Entrez Gene: 672 Human ; 497672 Rat

SwissProt: P38398 Human ; O54952 Rat

OMIM: 114480 Human

Documentation
SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

BRCA1 Antibody (YA819) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
BRCA1 Antibody (YA819)
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HY-P80489
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