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  5. beta Catenin Antibody (YA584)

beta Catenin Antibody (YA584)

Cat. No.: HY-P80488
COA
SDS
User Guide for Antibodies Technical Support

Beta-Catenin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Beta-Catenin. It can be used for WB,IHC-P,IF,IP assays with tag free, in the background of Human, Mouse,Rat.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

Publications Citing Use of MCE beta Catenin Antibody (YA584)

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Beta-Catenin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Beta-Catenin. It can be used for WB,IHC-P,IF,IP assays with tag free, in the background of Human, Mouse,Rat.
Background

Beta-catenin, a pivotal player in the canonical Wnt signaling pathway, dynamically regulates cellular processes in response to Wnt ligands. In the absence of Wnt, beta-catenin participates in a complex with AXIN1, AXIN2, APC, CSNK1A1, and GSK3B, promoting its phosphorylation and ubiquitination, leading to subsequent degradation by the proteasome. Upon Wnt activation, beta-catenin accumulates in the nucleus, acting as a coactivator for transcription factors of the TCF/LEF family, thereby activating Wnt-responsive genes. This multifaceted protein also plays a role in cell adhesion, acting as a component of an E-cadherin:catenin adhesion complex. Beyond these functions, beta-catenin emerges as a negative regulator of centrosome cohesion and exhibits roles in insulin internalization, inhibition of anoikis, and promotion of neurogenesis. It modulates chondrocyte differentiation, positively regulates odontoblast differentiation during tooth germ formation, and interacts with various proteins, including regulators and effectors of Wnt signaling, highlighting its central role in diverse cellular processes. Beta-catenin's complex network of interactions underscores its significance in orchestrating cellular responses to intricate signaling cues, contributing to the regulation of critical cellular functions.
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 85 kDa; Observed band size: 100 kDa
Purity

Protein A affinity purified.
Subcellular Location

Cytoplasm, Nucleus, Cell membrane, Cell junction
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Signal Transduction

Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500 ;IHC-P: 1:20-1:50 ;IF: 1:100 ;IP: Use at an assay dependent concentration.
Application

WB, IHC-P, ICC/IF, IP
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic peptide corresponding to Human Beta-Catenin.AA range:30-70.
Database

Entrez Gene: 1499 Human ; 12387 Mouse ; 84353 Rat

SwissProt: P35222 Human ; Q02248 Mouse ; Q9WU82 Rat

OMIM: 114500 Human

Documentation
SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

beta Catenin Antibody (YA584) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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beta Catenin Antibody (YA584)
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