Beclin 1 Antibody (YA4267)

Beclin 1 Antibody (YA4267) is a mouse-derived and non-conjugated IgG1 antibody, targeting to BECN1. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human.

Beclin 1 plays a central role in autophagy and acts as a core subunit of the PI3K complex, mediating the formation of phosphatidylinositol 3-phosphate. Different complex forms are involved in multiple membrane trafficking pathways: PI3KC3-C1 participates in autophagosome initiation, while PI3KC3-C2 is involved in autophagosome maturation and endocytosis. It also regulates degradative endocytic trafficking and is required for the abscission step in cytokinesis, likely in the context of PI3KC3-C2. Beclin 1 is essential for the formation of PI3KC3-C2 but not PI3KC3-C1. by similar: It may contribute to antiviral host defense; the mitochondrial-localized Beclin-1-C 35 kDa fragment can promote apoptosis by inducing mitochondrial translocation of BAX and the release of proapoptotic factors. (Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus.

Q14457

Predicted band size: 52 kDa; Observed band size: 60 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human BECN1 expressed in E. Coli.