BCR Antibody (YA3754)

BCR Antibody (YA3754) is a mouse-derived and non-conjugated IgG1 antibody, targeting to BCR. It can be applicated for WB, FC, ELISA assays, in the background of human.

Bcr is a protein with a unique structure that exhibits two opposing regulatory activities toward small GTP-binding proteins. Its C-terminus contains a GTPase-activating protein (GAP) domain, which stimulates GTP hydrolysis by RAC1, RAC2, and CDC42, accelerating their intrinsic GTP hydrolysis rate and downregulating the active GTP-bound form. The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF), promoting the conversion of CDC42, RHOA, and RAC1 from the GDP-bound to the GTP-bound state. The N-terminus possesses intrinsic kinase activity. Bcr serves as a key negative regulator of neuronal RAC1 activity (by similar). It also modulates macrophage functions, including CSF1-directed motility and phagocytosis, through RAC1 activity regulation. Additionally, Bcr acts as a major RHOA GEF in keratinocytes, playing a role in focal adhesion formation and keratinocyte differentiation.

P11274

Predicted band size: 143 kDa; Observed band size: 143 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human BCR (AA: 139-280) expressed in E. Coli.