BACH1 Antibody (YA2061)

BACH1 Antibody (YA2061) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BACH1.

BACH1 is a DNA-dependent ATPase and 5'-3' DNA helicase essential for maintaining chromosomal stability. It acts late in the Fanconi anemia pathway, following FANCD2 ubiquitination. BACH1 participates in homologous recombination repair of DNA double-strand breaks through its association with BRCA1 and facilitates the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links. Its helicase activity unfolds HMCES DNA-protein cross-links, enabling SPRTN metalloprotease to cleave the adduct. Additionally, BACH1 unwinds RNA:DNA substrates and G-quadruplex DNA (the latter requiring a 5'-single-stranded tail). by similar: BACH1 is involved in diverse DNA repair mechanisms, including homologous recombination and cross-link repair.

Q9BX63

Predicted band size: 141 kDa; Observed band size: 105 kDa

Affinity Purified

Non-conjugated

Unmodified

-

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000

WB

Liquid

Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human BACH1/BRIP1