Adipose Triglyceride Lipase Antibody (YA6009)

Adipose Triglyceride Lipase Antibody (YA6009) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATGL. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

ATGL catalyzes the initial step of triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets, exhibiting a strong preference for hydrolyzing long-chain fatty acid esters at the sn-2 position of the glycerol backbone and coordinating with LIPE/HLS and DGAT2 in the lipolytic cascade (By similarity). It also possesses acylglycerol transacylase and phospholipase A2 activities, transferring fatty acids from triglycerides to retinol, hydrolyzing retinyl esters, and generating 1,3-diacylglycerol from triglycerides. ATGL regulates adiposome size and may participate in adiposome degradation, while catalyzing the formation of fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes. It antagonizes LDAH in cellular lipid storage regulation, inhibits LDAH-stimulated lipid droplet fusion, and may play a key role in energy homeostasis (By similarity), enhancing triglyceride hydrolysis during starvation to supply free fatty acids for oxidation in other tissues.

Q96AD5

Predicted band size: 55 kDa; Observed band size: 55 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:200-1:1000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG