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  5. Atg16L1 Antibody (YA2187)

Atg16L1 Antibody (YA2187)

Cat. No.: HY-P82442
User Guide for Antibodies Technical Support

Atg16L1 Antibody (YA2187) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Atg16L1.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Atg16L1 Antibody (YA2187) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Atg16L1.
Background

ATG16L1 plays an essential role in both canonical and non-canonical autophagy pathways. It interacts with ATG12-ATG5 to mediate the lipidation of ATG8 family proteins (MAP1LC3A/B/C, GABARAPL1/2, and GABARAP), facilitating autophagosomal membrane elongation. In canonical autophagy, it catalyzes phosphatidylethanolamine (PE) conjugation to ATG8, while in non-canonical autophagy, it likely conjugates phosphatidylserine (PS) to ATG8 during single-membrane autophagy at endolysosomal compartments (e.g., limiting IAV infection). Additionally, ATG16L1 regulates MAVS-dependent type I interferon (IFN-I) production, suppresses NOD1/NOD2-driven inflammatory responses, and promotes antibacterial autophagy with NOD1/NOD2. By similarity, it recruits LRRK2 to stressed lysosomes and restricts lethal IAV infection in epithelial cells via non-canonical autophagy.
Gene ID
SwissProt ID
Synonyms
ATG16L1; APG16L; Autophagy-related protein 16-1; APG16-like 1
Molecular Weight

Predicted band size: 68 kDa; Observed band size: 68 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Cell Biology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:1000
Application

WB
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Recombinant protein of human ATG16L1
Database

Entrez Gene: 55054 Human ; 77040 Mouse ; 363278 Rat

SwissProt: Q676U5 Human ; Q8C0J2 Mouse ;

OMIM: 611081 Human

Documentation
User Guide for Antibodies (1077 KB)

Atg16L1 Antibody (YA2187) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Atg16L1 Antibody (YA2187)
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