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  5. ATG16L1 Antibody (YA2187)

ATG16L1 Antibody (YA2187)

Cat. No.: HY-P82442
User Guide for Antibodies Technical Support

ATG16L1 Antibody (YA2187) is a non-conjugated IgG antibody, targeting ATG16L1, with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). ATG16L1 Antibody (YA2187) can be used for WB experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

ATG16L1 Antibody (YA2187) is a non-conjugated IgG antibody, targeting ATG16L1, with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). ATG16L1 Antibody (YA2187) can be used for WB experiment in human, mouse, rat background.
Background

ATG16L1 plays an essential role in both canonical and non-canonical autophagy pathways. It interacts with ATG12-ATG5 to mediate the lipidation of ATG8 family proteins (MAP1LC3A/B/C, GABARAPL1/2, and GABARAP), facilitating autophagosomal membrane elongation. In canonical autophagy, it catalyzes phosphatidylethanolamine (PE) conjugation to ATG8, while in non-canonical autophagy, it likely conjugates phosphatidylserine (PS) to ATG8 during single-membrane autophagy at endolysosomal compartments (e.g., limiting IAV infection). Additionally, ATG16L1 regulates MAVS-dependent type I interferon (IFN-I) production, suppresses NOD1/NOD2-driven inflammatory responses, and promotes antibacterial autophagy with NOD1/NOD2. By similarity, it recruits LRRK2 to stressed lysosomes and restricts lethal IAV infection in epithelial cells via non-canonical autophagy.
Gene ID
SwissProt ID
Synonyms
ATG16L1; APG16L; Autophagy-related protein 16-1; APG16-like 1
Molecular Weight

Predicted band size: 68 kDa; Observed band size: 68 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Cell Biology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000
Application

WB
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Recombinant protein of human ATG16L1
Database

Entrez Gene: 55054 Human ; 77040 Mouse ; 363278 Rat

SwissProt: Q676U5 Human ; Q8C0J2 Mouse ;

OMIM: 611081 Human

Documentation
User Guide for Antibodies (1077 KB)

ATG16L1 Antibody (YA2187) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ATG16L1 Antibody (YA2187)
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