Arginase-1 Antibody (YA613)

Arginase-1 Antibody (YA613) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Arginase-1.

ARG1 is a key enzyme in the urea cycle, converting L-arginine to urea and L-ornithine, which is further metabolized into proline and polyamides that drive collagen synthesis and bioenergetic pathways essential for cell proliferation, respectively. The urea cycle occurs primarily in the liver and, to a lesser extent, in the kidneys. In nonhepatic tissues, ARG1 regulates L-arginine homeostasis by competing with nitric oxide synthase (NOS) and arginase for intracellular arginine. Arginine metabolism is a critical modulator of innate and adaptive immune responses. In polymorphonuclear granulocytes (PMN), ARG1 participates in an antimicrobial effector pathway. Upon PMN cell death, it is released from the phagolysosome, depleting arginine in the microenvironment and suppressing T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s), ARG1 promotes acute type 2 lung inflammation and supports optimal ILC2 proliferation (by similarity). In humans, the immunological role of ARG1 in the monocytic/macrophage/dendritic cell (DC) lineage remains uncertain.

Free

P05089

Predicted band size: 35 kDa; Observed band size: 37 kDa

Protein A affinity purified.

Cytoplasm, Cytoplasmic granule.

Non-conjugated

Unmodified

AB_3102055

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1:500; IHC-P: 1:1000

WB, IHC-P

Liquid

Supplied in 1*PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Synthetic peptide within Human Liver Arginase (C terminal)