FOXP3 Antibody (YA858)

FOXP3 Antibody (YA858) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXP3.

FOXP3, a pivotal transcriptional regulator, is indispensable for the development and inhibitory function of regulatory T-cells (Treg), playing a crucial role in maintaining immune system homeostasis. It acts as both a transcriptional repressor and activator, influencing the Treg lineage's suppressive function and stability, while modulating conventional T-cell expansion and function. FOXP3 coordinates the activation of key genes like CTLA4 and TNFRSF18, concomitant with the repression of cytokine-encoding genes such as interleukin-2 (IL2) and interferon-gamma (IFNG). Through its association with various transcription factors and chromatin modifiers, FOXP3 inhibits cytokine production, T-cell effector function, and the differentiation of IL17-producing helper T-cells (Th17), favoring Treg development. FOXP3's interactions with proteins like IKZF3, RUNX1, RORC, RELA, NFATC2, and others contribute to its diverse regulatory functions. Dimerization is essential for its transcriptional regulator activity, and it forms complexes with proteins such as STUB1, HSPA8, PPP1CA, PPP1CB, KAT5, HDAC7, USP7, ZFP90, TRIM28, RUNX2, RUNX3, and IKZF4.

Q9BZS1

Predicted band size: 47 kDa; Observed band size: 47 kDa

Non-conjugated

Unmodified

AB_3102013

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1:500-1:1000 ;IHC: 1:50-1:100

WB, IHC-P

Liquid

Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous