Anthrax Protective Antigen Antibody (YA1060)

Anthrax Protective Antigen Antibody (YA1060) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Anthrax Protective Antigen.

Anthrax Protective Antigen (PA) is one of the three protein components of anthrax toxin, mediating host cell attachment and translocation of edema factor (EF) and lethal factor (LF) into the cytoplasm. PA combined with LF forms lethal toxin (LeTx) causing death upon injection, while its association with EF produces edema toxin (EdTx) inducing edema. PA also confers immunity against anthrax infection. Mechanistically: 1) It binds host receptors ANTXR1/ANTXR2 for cellular attachment; 2) After furin cleavage into PA-63, it oligomerizes to form a pore for EF/LF translocation; 3) The low-pH-triggered conformational change of oligomeric PA-63 from pre-pore to pore state in endosomes facilitates toxin entry. by similar studies indicate clathrin-dependent endocytosis is required, and toxin components must unfold during pore-mediated translocation.

P13423

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Affinity Purified

Non-conjugated

Unmodified

Microbiology

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Bacillusanthracis

ELISA: 1:10000

ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Endogenous

A synthesized peptide derived from Anthrax Protective gen