AKT3 Antibody (YA4580)

AKT3 Antibody (YA4580) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AKT3.

AKT2, a crucial member of the AKT kinase family along with AKT1 and AKT3, orchestrates a myriad of cellular processes, including metabolism, proliferation, cell survival, growth, and angiogenesis. Operating through the phosphorylation of numerous downstream substrates, AKT2 influences over 100 reported targets, exhibiting remarkable functional diversity. It governs insulin-induced glucose uptake by facilitating SLC2A4/GLUT4 translocation and intricately regulates insulin signaling pathways. Additionally, AKT2 modulates glycogen storage, inhibits GSK3 kinase activity, and plays a pivotal role in the AKT-mTOR signaling pathway, influencing neurogenesis and cellular migration dynamics. AKT2's involvement in phosphorylating FOXO factors, CREB1, and multiple targets related to metabolism underscores its pivotal position in cellular homeostasis. Notably, AKT2 exhibits isoform-specific functions, with a significant role in regulating glucose uptake and participating in intricate processes such as skeletal muscle differentiation. The recent identification of specific substrates like PITX2 and ANKRD2 further delineates AKT2's nuanced and intricate cellular regulatory roles.

Q9Y243

Predicted band size: 56 kDa; Observed band size: 56 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal Antibody

Mouse

Human

IF: 1:50-1:250 FC: 1:200-1:400; ELISA: 1:10000

ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Purified recombinant fragment of human AKT3 (AA: 37-150) expressed in E. Coli.