ADAM15 Antibody (YA2650)

ADAM15 Antibody (YA2650) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2650), targeting ADAM15, with a predicted molecular weight of 93 kDa (observed band size: 90/100 kDa). ADAM15 Antibody (YA2650) can be used for WB, IHC-P experiment in human background.

ADAM15, an active metalloproteinase, exhibits gelatinolytic and collagenolytic activity, playing a crucial role in diverse physiological processes. Its involvement in wound healing is notable, and it mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Additionally, ADAM15 functions in inhibiting beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells, suppressing cell motility on or towards fibronectin by potentially influencing alpha-v/beta-1 integrin cell surface expression through ERK1/2 inactivation. Notably, ADAM15 cleaves E-cadherin in response to growth factor deprivation and contributes to glomerular cell migration, suggesting its involvement in various cellular events. Furthermore, its role in pathological neovascularization and potential contribution to cartilage remodeling underscore its multifaceted functions. ADAM15 may undergo proteolytic processing during sperm epididymal maturation and the acrosome reaction, potentially playing a role in sperm-egg binding through interactions with egg membrane receptors, particularly integrins.

Q13444

Predicted band size: 93 kDa; Observed band size: 90,100 kDa

Affinity Purified

Non-conjugated

Unmodified

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IHC: 1/50-1/100

WB, IHC-P

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human ADAM15