Actinin-α2 Antibody (YA5107)

Actinin-α2 Antibody (YA5107) is a mouse-derived and non-conjugated monoclonal antibody, targeting to actinin-α2. It can be applicated for WB, ICC/IF assays, in the background of human, rat, bovine, chicken, dog, pig, zebrafish.

Actinin α2 is the principal structural protein of cardiac Z-discs, functioning as an F-actin crosslinking protein that connects actin filaments to TTN filaments and maintains Z-disc integrity (by similar). Unlike Actinin α3 which is exclusively expressed in fast-twitch fibers, Actinin α2 is ubiquitously present in all skeletal and cardiac muscles, participating in mechanotransduction and metabolic regulation through interactions with various Z-disc proteins (e.g., titin, myotilin). Mutations in Actinin α2 are associated with hypertrophic and dilated cardiomyopathies, while the R577X polymorphism of Actinin α3 influences muscle power and endurance performance (by similar).

P35609

Predicted band size: 104 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Rat, Bovine, Chicken, Dog, Pig, Zebrafish

WB: 1:1000-1:2000; ICC/IF: 1:100-1:500

WB, ICC/IF

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human Actinin-α2 (C-terminus) protein fragments expressed in E.coli.