Acetyl Coenzyme A Carboxylase Antibody (YA6016)

Acetyl Coenzyme A Carboxylase Antibody (YA6016) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Acetyl Coenzyme A Carboxylase.

ACC-beta (acetyl-CoA carboxylase beta) is a mitochondrial enzyme that plays a central role in fatty acid metabolism by catalyzing the carboxylation of acetyl-CoA to malonyl-CoA. The reaction occurs in two steps: ATP-dependent carboxylation of biotin on the biotin carboxyl carrier (BCC) domain, followed by transfer of the carboxyl group to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). The product malonyl-CoA allosterically inhibits carnitine palmitoyltransferase 1, thereby negatively regulating fatty acid oxidation (by similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, it promotes lipid storage (by similarity).

O00763

Predicted band size: 227 kDa; Observed band size: 265 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:1000-1:4000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG