ABL1 Antibody (YA4762)

ABL1 Antibody (YA4762) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to ABL1.

ABL1, a non-receptor tyrosine-protein kinase, orchestrates diverse cellular processes crucial for growth and survival. Its multifaceted roles include coordinating cytoskeleton remodeling in response to extracellular cues, regulating cell motility, and influencing receptor endocytosis. ABL1's impact extends to autophagy, DNA damage response, and apoptosis, where it phosphorylates key substrates involved in these pathways. Notably, it modulates actin dynamics by phosphorylating proteins like WASF3 and ANXA1, influencing processes such as lamellipodia formation and cell migration. A critical player in cell adhesion and motility, ABL1 phosphorylates regulators like BCAR1 and CRK. Furthermore, it engages in the regulation of receptor tyrosine kinases, including the facilitation of EGFR endocytosis. ABL1's reach extends to mitochondrial function during oxidative stress, where it mediates dysfunction and cell death. Additionally, it translocates to the nucleus, contributing to DNA damage response, apoptosis, and the regulation of T-cell differentiation. ABL1's extensive substrate repertoire encompasses proteins involved in DNA repair and apoptosis, showcasing its central role in cellular homeostasis and response to external stimuli.

P00519

Predicted band size: 123 kDa;

affinity purified.

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human, Mouse

WB: 1:1,000; ICC/IF: 1:100; IHC-P: 1:200; FC: 1:1,000

WB, IHC-P, ICC/IF, FC

K-562 cell lysate, HeLa cell lysate, Daudi cell lysate, THP-1 cell lysate, K-562, human breast cancer tissue, human lung cancer tissue, mouse kidney tissue, HeLa.

Liquid

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Recombinant protein within human ABL1 aa 601-1,000 / 1,130.