ABCA1 Antibody (YA3573)

ABCA1 Antibody (YA3573) is a mouse-derived and non-conjugated IgG2a antibody, targeting to ABCA1. It can be applicated for IHC-P, ICC/IF, FC assays, in the background of human, mouse, rat, rabbit, monkey.

ABCA1 protein functions as a crucial catalyst in the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of the membrane, a process driven by ATP hydrolysis. This activity is integral to the transfer of phospholipids to apolipoproteins, leading to the formation of nascent high-density lipoproteins (HDLs). ABCA1 exhibits a preference for transporting phosphatidylcholine over phosphatidylserine and may play a similar role in the efflux of intracellular cholesterol to apolipoproteins, contributing to the generation of nascent HDLs. The mechanism involves the translocation of phospholipids from the outer face of the plasma membrane, forcing them through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain. This intricate process is essential for the regulation of lipid homeostasis and the maintenance of cellular and systemic lipid balance.

O95477

Predicted band size: 254 kDa; Observed band size: 254 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse, Rat, Rabbit, Monkey

IHC: 1/100-1/500; IF: 1/200-1/1000; FC: 1/200-1/400

IHC-P, ICC/IF, FC

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Purified recombinant fragment of human ABCA1 (AA: 2081-2261) expressed in E. Coli.