8-OHdG (DNA/RNA Damage) Antibody

8-OHdG (DNA/RNA Damage) Antibody is an unconjugated, approximately 0.283 kDa, rabbit-derived, anti-8-OHdG (DNA/RNA Damage) polyclonal antibody. 8-OHdG (DNA/RNA Damage) Antibody can be used for: ELISA, IHC-P, IHC-F, IF expriments in human, background without labeling.

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a marker formed in DNA after oxidation; guanine, the most sensitive base to free radical attack in DNA, can be converted to various markers such as 8-hydroxyguanine, 8-hydroxyguanosine, and 8-OHdG after oxidation. Among them, the 8-OHdG adduct is one of the most abundant base modifications excreted in urine, and due to its easy collection, it is commonly used as a biomarker for oxidative DNA damage. It is also the main product of DNA damage and can be used as an important biomarker to evaluate oxidative stress induced by exogenous compounds. Chronic arsenic exposure leads to elevated levels of urinary 8-OHdG, triclosan (TCS) exposure significantly increases 8-OHdG levels in zebrafish brain tissue, and levels of 8-OHdG in mitochondrial DNA isolated from the parietal cortex of patients with Alzheimer’s disease (AD) are significantly higher than those of age-matched controls. Additionally, the presence of 8-OHdG in DNA (also known as 8-hydroxyguanosine in RNA) is a reliable marker of base modifications, as it is consistently detected after oxidative stress generated by various conditions.

Predicted band size: 0.283kDa

affinity purified

Non-conjugated

Unmodified

Primary Antibody; Rabbit Polyclonal Antibody

Polyclonal

Rabbit

Species independent

ELISA: 1:5000-10000;IHC-P: 1:100-500;IHC-F: 1:100-500;IF: 1:100-500

ELISA, IHC-P, IHC-F, ICC/IF

Liquid

Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol or 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

KLH conjugated 8-OHdG