4-1BBL Antibody (YA2316)

4-1BBL Antibody (YA2316) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2316), targeting 4 1BBL, with a predicted molecular weight of 27 kDa (observed band size: 25-32 kDa). 4-1BBL Antibody (YA2316) can be used for WB, IP experiment in human background.

4-1BBL is expressed on a variety of antigen presenting cells (APCs), including activated B cells, dendritic cells, macrophages, and myeloid cells . The amino acid sequence of the human 4-1BBL protein has low homology to the mouse and rat 4-1BBL proteins. 4-1BBL binds to 4-1BB with high affinity, leading to the recruitment of intracellular TRAF adaptor molecules (TRAF1 and TRAF2), which then activate the NF-κB and extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-associated protein (MAP) kinase signaling cascades. The binding of 4-1BBL to 4-1BB generates a strong co-stimulatory signal in T cells, leading to upregulation of anti-apoptotic molecules, cytokine secretion, and enhanced effector function . 4-1BBL is a member of the TNF protein family. 4-1BBL is an immunostimulatory molecule that interacts with the 4-1BB high-affinity receptor during antigen presentation, providing co-stimulatory signals to CD4+ and CD8+ T cells by activating NF-kB, c-Jun and p38 downstream pathways, triggering pleiotropic effects on the immune system. 4-1BBL significantly induces T cell proliferation and increases stimulation by IL-2 and IFN-γ.

P41273

Predicted band size: 27 kDa; Observed band size: 25-32 kDa

Affinity Purified

Non-conjugated

Unmodified

Immunology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IP: 1/50

WB, IP

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human TNFSF9