4-1BB Ligand Antibody (YA1329)

4-1BB Ligand Antibody (YA1329) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1329), targeting 4-1BB Ligand. 4-1BB Ligand Antibody (YA1329) can be used for FC, ELISA experiment in human background.

4-1BBL is expressed on a variety of antigen presenting cells (APCs), including activated B cells, dendritic cells, macrophages, and myeloid cells . The amino acid sequence of the human 4-1BBL protein has low homology to the mouse and rat 4-1BBL proteins. 4-1BBL binds to 4-1BB with high affinity, leading to the recruitment of intracellular TRAF adaptor molecules (TRAF1 and TRAF2), which then activate the NF-κB and extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-associated protein (MAP) kinase signaling cascades. The binding of 4-1BBL to 4-1BB generates a strong co-stimulatory signal in T cells, leading to upregulation of anti-apoptotic molecules, cytokine secretion, and enhanced effector function . 4-1BBL is a member of the TNF protein family. 4-1BBL is an immunostimulatory molecule that interacts with the 4-1BB high-affinity receptor during antigen presentation, providing co-stimulatory signals to CD4+ and CD8+ T cells by activating NF-kB, c-Jun and p38 downstream pathways, triggering pleiotropic effects on the immune system. 4-1BBL significantly induces T cell proliferation and increases stimulation by IL-2 and IFN-γ.

P41273

Predicted band size: 27 kDa; Observed band size: 25-32 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Immunology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

FC: 1/50-1/100;ELISA: 1/10000

FC, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant human 4-1BB Ligand protein