Anamorelin Fumarate  (Synonyms: RC-1291 Fumarate; ONO-7643 Fumarate)

Anamorelin (RC-1291) Fumarate is an orally active Ghrelin receptor agonist with an EC₅₀ of 0.74 nM. Anamorelin Fumarate can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin Fumarate can be used in the research of anorexia and cancer cachexia^[1][2].

K_i: 0.7 nM (Ghrelin receptor)^[1]
EC₅₀: 0.74 nM (Ghrelin receptor)^[1]

Anamorelin (0.01 nM-10 μM; 15 min) Fumarate stimulates growth hormone release in a dose-dependent manner in rat pituitary cells, with an EC₅₀ of 1.5 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anamorelin (3-30 mg/kg; oral administration; 6 days) Fumarate increases food intake and body weight in rats in a dose-dependent manner^[1].
Anamorelin (3.5 mg/kg; oral administration; 1-7 days) Fumarate significantly elevates the levels of growth hormone and insulin-like growth factor-1 in pigs^[1].
Anamorelin (3-30 mg/kg; oral administration; 28 days) Fumarate does not promote tumor growth in a nude mouse model of lung cancer xenografts, but increases the body weight of nude mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

662.78

C₃₅H₄₆N₆O₇

339539-92-3

[H][C@](CC1=CNC2=CC=CC=C21)(NC(C(C)(C)N)=O)C(N3CCC[C@@](C(N(C)N(C)C)=O)(CC4=CC=CC=C4)C3)=O.O=C(O)/C=C/C(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):329-37.  [Content Brief]

  [2]. Northrup R, et al. Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model. Support Care Cancer. 2013 Sep;21(9):2409-15.  [Content Brief]