Aluminum hydroxide adjuvant 

Aluminum hydroxide adjuvant is a vaccine adjuvant. The aluminum content is 9-11 mg/mL. Aluminum hydroxide adjuvant induces the differentiation of macrophages into a new type of mature, specialized antigen-presenting cells in vitro^[1]. It has a strong adsorption capacity for negatively charged antigens, a significant sustained-release effect, no stress response, high safety, and can effectively induce immune responses in the body. It is suitable for various veterinary vaccines, including inactivated vaccines or gene-engineered subunit vaccines for bacterial and viral diseases of livestock and poultry. It is suitable for various veterinary vaccines, including inactivated vaccines or gene-engineered subunit vaccines for bacterial and viral diseases of livestock and poultry.

Filtration of the antigen before mixing with the adjuvant is recommended.

1. Shake the adjuvant thoroughly before use.

2. Mix adjuvant with antigen solution at a 1:9 ratio (100μL adjuvant per 900μL antigen):

a. Add adjuvant dropwise with constant mixing to the immunogen solution.

b. Pipet up and down several times to ensure correct absorption of antigen by adjuvant and incubate ~10 minutes.

NOTE: Ratio can be optimized from 1:1 to 1:9.

3. Inject into the animal, the volume depends on the site of injection.

Note: After opening, store the product refrigerated at 2–8°C and used within 3 months as soon as possible. Avoid high temperature, high pressure, and repeated freezing and thawing.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Liquid

White to off-white

[Aluminum hydroxide adjuvant]

Room temperature in continental US; may vary elsewhere.

• [1]. Rimaniol AC, et al. Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type. Vaccine. 2004 Aug 13;22(23-24):3127-35.  [Content Brief]