2. Adjuvant
  3. Nucleic Acid Adjuvant
  4. Cyclic Dinucleotides

Cyclic Dinucleotides

Cyclic Dinucleotides (18):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-100564
    2',3'-cGAMP 1441190-66-4 99.95%
    2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.
    2',3'-cGAMP
  • HY-12885A
    2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt 1638750-95-4 99.91%
    2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).
    2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt
  • HY-100564A
    2',3'-cGAMP sodium 2734858-36-5 99.89%
    2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm.
    2',3'-cGAMP sodium
  • HY-12885B
    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt 1638750-96-5 99.89%
    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.
    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • HY-12512
    cGAMP 849214-04-6 99.22%
    cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
    cGAMP
  • HY-12326A
    c-di-AMP disodium 2734909-87-4 99.14%
    c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
    c-di-AMP disodium
  • HY-110385
    cGAMP disodium 2407516-83-8 98.47%
    cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
    cGAMP disodium
  • HY-110382
    Cyclic-di-GMP disodium 2222132-40-1 98.78%
    Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research.
    Cyclic-di-GMP disodium
  • HY-12885
    2’3’-c-di-AM(PS)2 (Rp,Rp) 1638241-89-0 99.85%
    2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.
    2’3’-c-di-AM(PS)2 (Rp,Rp)
  • HY-107780B
    Cyclic-di-GMP diammonium 609343-82-0 99.07%
    Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research.
    Cyclic-di-GMP diammonium
  • HY-N8245
    2',3'-cGMP sodium 15718-49-7 99.28%
    2',3'-cGMP sodium, a cGMP analogue, is an intermediate of RNA catalytic cleavage by binase.
    2',3'-cGMP sodium
  • HY-12326B
    c-di-AMP diammonium 99.36%
    c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
    c-di-AMP diammonium
  • HY-110385A
    cGAMP diammonium
    cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
    cGAMP diammonium
  • HY-12326
    c-di-AMP 54447-84-6 99.29%
    c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
    c-di-AMP
  • HY-107780
    Cyclic-di-GMP 61093-23-0 98.18%
    Cyclic-di-GMP is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP can be used in cancer research.
    Cyclic-di-GMP
  • HY-134375
    cAIMP 1507367-51-2
    cAIMP (Cyclic Adenosine-Inosine Monophosphate) is an effective synthetic cyclic dinucleotide. cAIMP activates IRF and NF-κB in the THP1 human monocyte reporter cell line (THP1-Dual). cAIMP induces the secretion of IFNs and pro-inflammatory cytokines in vitro in human blood, with an EC50 of 6.4 μmol/L.
    cAIMP
  • HY-137709
    2'2'-cGAMP 1465774-27-9
    2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP binds weaker binding to STING than 2'3'-cGAMP (HY-100564) but stronger than other CDNs.
    2'2'-cGAMP
  • HY-107780A
    Cyclic-di-GMP sodium
    Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research.
    Cyclic-di-GMP sodium