2. Metabolic Enzyme/Protease
  3. Acetyl-CoA Carboxylase
  4. AD-5584

AD-5584 is an ACSS2 inhibitor with blood-brain permeability. AD-5584 can significantly reduce lipid storage, reduce colony formation, and increase cell death. AD-5584 has antitumor activity.

For research use only. We do not sell to patients.

AD-5584 Chemical Structure

AD-5584 Chemical Structure

CAS No. : 2306525-79-9

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Description

AD-5584 is an ACSS2 inhibitor with blood-brain permeability. AD-5584 can significantly reduce lipid storage, reduce colony formation, and increase cell death. AD-5584 has antitumor activity[1].

IC50 & Target

ACSS2[1]
Molecular Weight

414.90

Formula

C22H24ClFN4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(C(N2CCCCC2)C(N(C)CC3=NC4=CC(Cl)=CC=C4N3)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (30.13 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4102 mL 12.0511 mL 24.1022 mL
5 mM 0.4820 mL 2.4102 mL 4.8204 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.86%

SDS (251 KB)

COA (255 KB) HNMR (293 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4102 mL 12.0511 mL 24.1022 mL 60.2555 mL
5 mM 0.4820 mL 2.4102 mL 4.8204 mL 12.0511 mL
10 mM 0.2410 mL 1.2051 mL 2.4102 mL 6.0255 mL
15 mM 0.1607 mL 0.8034 mL 1.6068 mL 4.0170 mL
20 mM 0.1205 mL 0.6026 mL 1.2051 mL 3.0128 mL
25 mM 0.0964 mL 0.4820 mL 0.9641 mL 2.4102 mL
30 mM 0.0803 mL 0.4017 mL 0.8034 mL 2.0085 mL
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AD-5584 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AD-55842306525-79-9AD5584AD 5584Acetyl-CoA CarboxylaseACC, Acetyl Coenzyme A CarboxylaseMDA-MB-231BRACSS2InhibitorAntitumorinhibitorinhibit

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