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  4. ACHM-025

ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia.

For research use only. We do not sell to patients.

ACHM-025

ACHM-025 Chemical Structure

CAS No. : 2377718-85-7

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ACHM-025 Related Antibodies

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Description

ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia[1].

In Vitro

ACHM-025 exhibits potent cytotoxic activity only against AKR1C3-overexpressing HCT116 cells with an IC50 of 0.03 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ACHM-025 Related Antibodies
In Vivo

ACHM-025 (25 mg/kg, i.p., at days 0, 7, 14) significantly reduces the proportion of human leukemia cells in peripheral blood and prolongs survival in female NOD/SCID or NSG mice inoculated with chemoresistant T-ALL PDX (ALL-31)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID or NSG mice inoculated with chemoresistant T-ALL PDX (ALL-31)[1]
Dosage: 25 mg/kg
Administration: Intraperitoneally injection, at days 0, 7, 14
Result: Reduced the proportion of human leukemia cells in peripheral blood to <1% and maintained it for more than 10 weeks.
Extended the median event-free survival (EFS) from 16.7 days to >332 days.
Showed no relapse within the >300-day observation period, and no leukemia cells are detected in organs such as bone marrow and spleen after dissection, achieving functional cure in 5 mice.
Molecular Weight

544.62

Formula

C17H28N4O10S3
CAS No.
SMILES

O=S(C1=CC([N+]([O-])=O)=CC=C1N(CCOS(=O)(C)=O)CCOS(=O)(C)=O)(N2CCN(CC2)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ACHM-025 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACHM-0252377718-85-7ACHM025ACHM 025OthersProdrugAKR1C3nitrogen mustard DNA alkylating agentleukemiaInhibitorinhibitorinhibit

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