2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Acetophenazine

Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks dopamine D2 receptors in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression.

For research use only. We do not sell to patients.

Acetophenazine

Acetophenazine Chemical Structure

CAS No. : 2751-68-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Acetophenazine:

Acetophenazine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Acetophenazine

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks dopamine D2 receptors in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression[1][2].

IC50 & Target[1]

D2 Receptor

 

In Vivo

Acetophenazine (2.4 mg/kg; i.h.; single dosage) significantly prolongs the time lapse from the first fight to submission and the actual fighting time to submission in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL mice (10-12 weeks)[3]
Dosage: 2.4 mg/kg
Administration: i.h.; single dosage
Result: Significantly prolonged the time lapse from the first fight to submission and the actual fighting time to submission.
Molecular Weight

411.56

Formula

C23H29N3O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C1=CC=C(SC2=C3C=CC=C2)C(N3CCCN4CCN(CC4)CCO)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (242.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4298 mL 12.1489 mL 24.2978 mL
5 mM 0.4860 mL 2.4298 mL 4.8596 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.07 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4298 mL 12.1489 mL 24.2978 mL 60.7445 mL
5 mM 0.4860 mL 2.4298 mL 4.8596 mL 12.1489 mL
10 mM 0.2430 mL 1.2149 mL 2.4298 mL 6.0744 mL
15 mM 0.1620 mL 0.8099 mL 1.6199 mL 4.0496 mL
20 mM 0.1215 mL 0.6074 mL 1.2149 mL 3.0372 mL
25 mM 0.0972 mL 0.4860 mL 0.9719 mL 2.4298 mL
30 mM 0.0810 mL 0.4050 mL 0.8099 mL 2.0248 mL
40 mM 0.0607 mL 0.3037 mL 0.6074 mL 1.5186 mL
50 mM 0.0486 mL 0.2430 mL 0.4860 mL 1.2149 mL
60 mM 0.0405 mL 0.2025 mL 0.4050 mL 1.0124 mL
80 mM 0.0304 mL 0.1519 mL 0.3037 mL 0.7593 mL
100 mM 0.0243 mL 0.1215 mL 0.2430 mL 0.6074 mL
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Acetophenazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acetophenazine2751-68-0Dopamine ReceptorPhenothiazineantipsychoticpsychotic disordersschizophreniaanxious depressionInhibitorinhibitorinhibit

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