β-Alanine (Synonyms: 2-Carboxyethylamine; 3-Aminopropanoic acid)

Name: β-Alanine
Brand: MedChemExpress
SKU: HY-N0230
Rating: 5.0 (2 reviews)

Cat. No.: HY-N0230 Purity: ≥98.0%: Data Sheet
COA

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Handling Instructions
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β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

For research use only. We do not sell to patients.

β-Alanine Chemical Structure

CAS No. : 107-95-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote
5 g	Get quote

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Based on 2 publication(s) in Google Scholar

Other Forms of β-Alanine:

2 Publications Citing Use of MCE β-Alanine

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Biological Activity
Purity & Documentation
References
Customer Review

Description

β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.

IC₅₀ & Target

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	> 100 μM Compound: beta-alanine	Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis	[PMID: 25147609]
CHO	IC₅₀	209 μM Compound: beta-alanine	Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis	[PMID: 23886812]
CHO	IC₅₀	41.2 μM Compound: beta-alanine	Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis	[PMID: 25147609]
CHO	IC₅₀	41.2 μM Compound: beta-alanine	Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis	[PMID: 23886812]

In Vitro

Cells treated with β-alanine display significantly suppressed basal and peak ECAR (aerobic glycolysis), with simultaneous increase in glucose transporter 1 (GLUT1). Additionally, cells treated with β-alanine exhibit significantly reduced basal and peak OCR (oxidative metabolism), which is accompanied by reduction in mitochondrial content with subsequent suppression of genes which promote mitochondrial biosynthesis. Suppression of glycolytic and oxidative metabolism by β-alanine results in the reduction of total metabolic rate, although cell viability is not affected.β-alanine is shown to reduce both cell migration and proliferation without acting in a cytotoxic fashion. Moreover, β-alanine significantly increases malignant cell sensitivity to doxorubicin, suggesting a potential role as a co-therapeutic agent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

89.09

Formula

C₃H₇NO₂

CAS No.

107-95-9

Appearance

Solid

Color

White to off-white

SMILES

NCCC(O)=O

Structure Classification

Amino acids

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 33.33 mg/mL (374.10 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	11.2241 mL	56.1205 mL	112.2410 mL
5 mM	2.2448 mL	11.2241 mL	22.4482 mL
10 mM	1.1224 mL	5.6121 mL	11.2241 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (561.21 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (269 KB) SDS (394 KB)

COA (242 KB) HNMR (245 KB)

Handling Instructions (2659 KB)

References

[1]. Vaughan RA, et al. β-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro. Mol Cancer. 2014 Jan 24;13:14. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	11.2241 mL	56.1205 mL	112.2410 mL	280.6025 mL
	5 mM	2.2448 mL	11.2241 mL	22.4482 mL	56.1205 mL
	10 mM	1.1224 mL	5.6121 mL	11.2241 mL	28.0603 mL
	15 mM	0.7483 mL	3.7414 mL	7.4827 mL	18.7068 mL
	20 mM	0.5612 mL	2.8060 mL	5.6121 mL	14.0301 mL
	25 mM	0.4490 mL	2.2448 mL	4.4896 mL	11.2241 mL
	30 mM	0.3741 mL	1.8707 mL	3.7414 mL	9.3534 mL
	40 mM	0.2806 mL	1.4030 mL	2.8060 mL	7.0151 mL
	50 mM	0.2245 mL	1.1224 mL	2.2448 mL	5.6121 mL
	60 mM	0.1871 mL	0.9353 mL	1.8707 mL	4.6767 mL
	80 mM	0.1403 mL	0.7015 mL	1.4030 mL	3.5075 mL
	100 mM	0.1122 mL	0.5612 mL	1.1224 mL	2.8060 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

β-Alanine Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Alanine107-95-92-Carboxyethylamine 3-Aminopropanoic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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β-Alanine (Synonyms: 2-Carboxyethylamine; 3-Aminopropanoic acid)

Customer Review

Other Forms of β-Alanine:

β-Alanine Related Antibodies

2 Publications Citing Use of MCE β-Alanine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

β-Alanine Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

β-Alanine Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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