2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. Troxacitabine

Troxacitabine  (Synonyms: BCH 4556; L-OddC; SPD 758)

Cat. No.: HY-13770 Purity: 99.95%
COA
SDS
Handling Instructions Technical Support

Troxacitabine is nucleoside analog with potent anticancer activity.

For research use only. We do not sell to patients.

Troxacitabine

Troxacitabine Chemical Structure

CAS No. : 145918-75-8

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Customer Review

Based on 1 publication(s) in Google Scholar

Troxacitabine Related Antibodies

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  • Biological Activity

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Description

Troxacitabine is nucleoside analog with potent anticancer activity.

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.68 μM
Compound: 5
Cytotoxicity against A549 cells after 72 hrs by SRB assay
Cytotoxicity against A549 cells after 72 hrs by SRB assay
[PMID: 17419604]
CCRF-CEM IC50
> 1 μM
Compound: beta-L-cytosine
Compound was evaluated for cytotoxicity by inhibition of mitochondrial DNA synthesis
Compound was evaluated for cytotoxicity by inhibition of mitochondrial DNA synthesis
10.1016/0960-894X(95)00343-R
SW1573 IC50
2.3 μM
Compound: 5
Cytotoxicity against SW1573 cells after 72 hrs by SRB assay
Cytotoxicity against SW1573 cells after 72 hrs by SRB assay
[PMID: 17419604]
In Vitro

Troxacitabine has shown cutotoxicity in cancer cell lines of hepatocellular (HepG2), prostate (PC3, DUI45), non-small cell lung (NCI-H460, NCr-322M) colon (HT29), renal (CAK-l, A498, RXF-393, SNI2-C) and pancreatic origin (Pnac-Ol, MiaPa Ca) with IC50s range from 15-35 μM[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Troxacitabine Related Antibodies
In Vivo

Troxacitabine is highly active against the Panc-01 model, with TGI levels of 88.5% and 84.3% at the 10 and 25 mg/kg doses, respectively. The mean final tumor weights for animals given troxacitabine are also significantly smaller compared with vehicle controls. Troxacitabine has less activity against the MiaPaCa model[3]. Troxacitabine is very effective in human RCC tumor xenograft models, including CAM-i, A498, RXF-393, and SN12C carcinomas. Very good responses are ob served in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

213.19

Formula

C8H11N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(N(C=C1)[C@@H]2CO[C@H](CO)O2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (93.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6907 mL 23.4533 mL 46.9065 mL
5 mM 0.9381 mL 4.6907 mL 9.3813 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

SDS (393 KB)

COA (252 KB) RP-HPLC (247 KB) MS (68 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[3]

Mice[3]

Troxacitabine is administered i.v. to the animals at doses of 10 and 25 mg/kg on a daily 3 5 regimen. Gemcitabine is used as a positive control. The end points for the study included tumor growth inhibition (TGI), final weight, and the number of partial and complete tumor responses in the animals[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6907 mL 23.4533 mL 46.9065 mL 117.2663 mL
5 mM 0.9381 mL 4.6907 mL 9.3813 mL 23.4533 mL
10 mM 0.4691 mL 2.3453 mL 4.6907 mL 11.7266 mL
15 mM 0.3127 mL 1.5636 mL 3.1271 mL 7.8178 mL
20 mM 0.2345 mL 1.1727 mL 2.3453 mL 5.8633 mL
25 mM 0.1876 mL 0.9381 mL 1.8763 mL 4.6907 mL
30 mM 0.1564 mL 0.7818 mL 1.5636 mL 3.9089 mL
40 mM 0.1173 mL 0.5863 mL 1.1727 mL 2.9317 mL
50 mM 0.0938 mL 0.4691 mL 0.9381 mL 2.3453 mL
60 mM 0.0782 mL 0.3909 mL 0.7818 mL 1.9544 mL
80 mM 0.0586 mL 0.2932 mL 0.5863 mL 1.4658 mL
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Troxacitabine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Troxacitabine145918-75-8BCH 4556 L-OddC SPD 758BCH4556BCH-4556SPD758SPD 758SPD-758Nucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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