2. Signaling Pathways
  3. Epigenetics
  4. WDR5

WDR5

WD repeat protein-5; WD40 repeat domain protein 5

WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding component of histone methyltransferase complexes. WDR5 also plays a crucial role in mediating protein-protein interactions that sustain oncogenesis in human cancers. One prominent example is the interaction between the transcription factor MYC and WDR5, which is essential for oncogenic processes.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-175802
    HBI-2375
    		Inhibitor
    HBI-2375 (HYBI-084) is a selective, brain-penetrant and orally active MLL1-WDR5 interaction inhibitor. HBI-2375 inhibits WDR5 with an IC50 of 4.48 nM. HBI-2375 shows inhibition of proliferation in MV4;11 leukemia cells (IC50: 3.17 µM). HBI-2375 is capable of targeted disruption of histone methyltransferase activity in cancer cells. HBI-2375 can be used for the study of leukemia, glioma and glioblastoma.
    HBI-2375
  • HY-174255
    WDR5-MYC-IN-2
    		Inhibitor
    WDR5-MYC-IN-2 is an inhibitor of WDR5-MYC protein-protein interaction (PPI) with IC50 of 0.59 μM. WDR5-MYC-IN-2 can be studied in research for MYC-driven cancer and development of other effective WDR5-MYC PPI inhibitors.
    WDR5-MYC-IN-2
  • HY-150400A
    XF056-132
    		Degrader
    XF056-132 is the salt form of trifluoroacetic acid (TFA, HY-21182).
    XF056-132
  • HY-168487
    PROTAC WDR5 degrader 1
    		Inhibitor
    PROTAC WDR5 degrader 1 (compound 8g) is a PROTAC degrader targeting WDR5. PROTAC WDR5 degrader 1 is composed of a target protein ligand (red part) WDR5 ligand 2 (HY-168488), a VHL-type E3 ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and a PROTAC linker (balck part) 5-Aminovaleric acid (HY-W015878), in which the VHL ligand and the PROTAC linker form a conjugate (HY-114176A).
    PROTAC WDR5 degrader 1
  • HY-19554
    MM-401
    		Inhibitor
    MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia.
    MM-401
  • HY-163774
    WDR5-MYC-IN-1
    		Inhibitor
    WDR5-MYC-IN-1 (compound 4o) is a potent WDR5-MYC interaction inhibitor with a Ki value of 1.0 µM. WDR5-MYC-IN-1 shows antiproliferative activity.
    WDR5-MYC-IN-1
  • HY-168488
    WDR5 ligand 2
    		Ligand
    WDR5 ligand 2 is the ligand for WDR5 and can be used for synthesis of PROTAC WDR5 degrader 1 (HY-168487).
    WDR5 ligand 2
Cat. No. Product Name / Synonyms Application Reactivity