2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. SWI/SNF Complex
  5. SMARCA2 Isoform
  6. SMARCA2 Degrader

SMARCA2 Degrader

SMARCA2 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-176871
    PROTAC SMARCA2 degrader-35
    		Degrader
    PROTAC SMARCA2 degrader-35 (Compound 43) is a selective SMARCA2 PROTAC degrader with a DC50 < 0.1 μM for SMARCA2. PROTAC SMARCA2 degrader-35 has anticancer activity and regulates cancer cell proliferation and growth through cell cycle arrest and DNA replication inhibition in SMARCA4-deleted cancer cells. Pink: SMARCA2 ligand (HY-178414); Blue: E3 ligase ligand; Black: linker