2. Signaling Pathways
  3. Epigenetics
  4. Small Interfering RNA (siRNA)
  5. Small Interfering RNA (siRNA) Degrader

Small Interfering RNA (siRNA) Degrader

Small Interfering RNA (siRNA) Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-176457
    ZS3-046
    		Degrader
    ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model. (Target protein ligand (HY-176467); CRBN ligase (HY-41547); Linker (HY-176469); CRBN ligase + Linker (HY-176450)).